Acne Explained

Acne affects about 80% of people at some point in their lives. It is a chronic, inflammatory disorder of the sebaceous (oil) gland in the skin. It can have a huge psychosocial impact on sufferers, with many people suffering low mood and unhappiness as a direct consequence of the condition.

It is primarily caused by increased levels of androgen hormones that causes a number of changes in the skin:

1. Excess sebum (oil) production
2. Follicle plugging from cellular debris
3. Excitation of Propionibacterium Acnes (P. Acnes)
4. Inflammatory cascade

In order to treat acne thoroughly all four of these factors need to be addressed.

Treatment options with topical skincare:

1. Salicylic Acid – a beta hydroxy-acid (BHA) derived from willow bark. Salicylic is lipid soluble and is very effective at getting through the sebum that clogs pores. It also helps to reduce cellular debris and to smooth the skin and has anti-microbial activity so it can help kill off bacteria in the skin. Over the counter products contain low levels of salicylic acid normally because of its natural drying effect on the skin. Look for levels between 2-5% in your products if you actually want to see a rapid and significant improvement in your skin. Caution: salicylic acid has a drying effect on the skin for a few weeks but this generally settles with continued use. For moderate to severe acne 15-30% salicylic acid peels can be done in medical clinics. TRY: ZENii Salicylic Exfoliator 2% AM & PM.

2. Follicle plugging (micro-comedones) can be treated with regular exfoliation of the skin. With acne its worth avoiding mechanical exfoliators that rub and abrade the skin and instead favour chemical ones like glycolic acid, lactic acid, pyruvic acid and mandelic acid. Glycolic acid is a water soluble Alpha Hydroxy-acid (AHA) that is fantastic for removing superficial cellular debris. It doesn’t penetrate very deep into the skin because its water soluble (lipid soluble ones like salicylic acid penetrate deeper) but it is the most trusted and researched AHA on the market. Strengths varying anywhere from 5-10% are effective for acne without being unduly irritating. Other good options are fruit acids, lactic acid and mandelic acid. Many chemical exfoliators combine a few of these different chemicals to improve the synergy or overall effect. TRY: ZENii Clarifying Masque (Gycolic Acid & Zinc Oxide) or ZENii Fruit Acid Exfoliator 7.5% with Kojic acid.

3. Propionibacterium acnes – This bacteria thrives in an oil rich, follicle plugged environment and the bacteria feed off the excess oil in the skin. Proliferation of the Proprionibacterium Acnes bacteria is responsible for most cases of acne (although we are seeing a few new strains coming through) and it is often resistant to antibiotics used to treat acne. For this reason many physicians are avoiding antibiotics in the management of acne. In addition oral antibiotics can kill off the good bacteria that reside in the gut causing long term digestive & immune problems. Instead of antibiotics benzoyl peroxide can be used for bacterial reduction and lasers and light therapy can be helpful too. Many physicians are also putting their acne patients onto probiotics to help replace the any destroyed beneficial bacterial secondary to antibiotic therapy. TRY: ZENii Probiotics or Digestive Health

4. Inflammatory cascade – This is a complex process in acne and occurs when all of the above conditions are met – excess oil, microplugging & proliferation of bacteria. The actual inflammatory culprit is lipase, a chemical produced by excessive growth of P. Acnes. The lipase breaks down the oil’s triglycerides releasing fatty acids. And these fatty acids cause the localised inflammation.
Retain A products (also known as Tretinoin) are effective at reducing localised inflammation and help improve skin cell turnover. They are also good for reducing the pink/purple discolouration of prolonged inflammatory acne. They are a prescription strength product with good efficacy in most acne patients. Over the counter retinols are a good alternative if you cannot see a doctor and can be used in the long term for maintenance & remission. 0.5 -1% retinol is ideal. Caution: Vitamin A based skincare (retinols & tretionin) can irritate the skin. Use them cautiously, start gently and increase usage slowly as the skin allows. Any initial redness and dryness should settle with continued use. TRY: ZENii Advanced Retinol 1% Complex

Extra tips: Always avoid heavy & congesting make up and opt for mineral technology that allows the skin to breathe. Choose moisturisers and sun protectors that are water based and oil free such as hyaluronic acid serums. Products will often guide you on this point by using the term ‘non-comedogenic’ which means that it wont clog you pores. TRY: ZENii oil free Hyaluronic Booster Serum

Lifestyle measures:

There is significant evidence nowadays that avoidance of dairy, gluten and sugar reduces acne.

~ Cows milk often contains added hormones so should be avoided. It also increases a growth factor called IGF-1 which exacerbates acne through stimulation of hormones.

~ Gluten, a protein found in wheat and other grains like oat, barley and rye can also excite an inflammatory response in the body resulting in inflammation and acne. Gluten acts in 2 ways. Firstly it can cause leaky gut which is where microscopic weaknesses in the gut lining allow toxins to recirculate back into the system with resultant inflammation. Secondly, because gluten sensitive people cannot digest gluten, these large molecules enter the circulation and the immune system launches an attack on them. This immune response triggers the release of insulin and IGF-1 which raises hormone levels and triggers acne.

Research shows that IGF-1:

~ Increases acne severity
~ Increases sebum production
~ Increases pore size making them more visible.

Both dairy and gluten should be avoided in anyone suffering from acne.

~ Sugar is also something that should be avoided as it triggers the release of insulin and IGF-1. As you eat carbohydrates, especially sugar, your blood sugar level increases. The pancreas then responds by making insulin, a hormone which takes sugar up into the cells and reduces blood sugar levels. Increased insulin secretion increases IGF-1 which further increases sebum and exacerbates acne. Sugar also stimulates inflammation and can feed any candida in the skin.

In short sugar, gluten and dairy all aggravate the two major causes of acne: hormones and inflammation. All of these should be avoided if you have acne.


It should be obvious by now that everything that you put into your body is inextricably linked with the quality of your skin. Your skin is, after all your largest organ and is simply a reflection of what you put inside your body.

Healthy skin starts from within:

The main beneficial micronutrients that help control and reduce acne are:

~ Omega 3 (fish, krill or flaxseed)
~ Vitamin B complexes
~ Zinc
~ Magnesium
~ Vitamin D
~ Vitamin C
~ Vitamin A
~ Probiotics

Try: ZENii Clear Skin, ZENii Omegas & ZENii Probitotics

Dr Johanna Ward

Dr Johanna Ward

Dr Ward is the founder of ZENii. She is known for her depth of knowledge in dermatology and nutrition and her passion for anything to do with health. She has devoted her professional career to understanding the science of skin health and created ZENii out of a true passion and understanding of skincare at the cellular level. Quality and clinical integrity are what underpins all of her formulations.

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